Function and Aggregation in Structural Eye Lens Crystallins
نویسندگان
چکیده
منابع مشابه
Prediction of Aggregation Sites in Human Eye Lens γ-Crystallins: Implications in Cataract
Cataract, a leading cause of blindness, occurs due to aggregation of crystallin proteins in eye lens. In this paper, the aggregation site in three major γ-crystallins of human eye lens has been identified unambiguously by using their primary sequences with the help of PASTA, Tango and AGGRESCAN. We have found that some hydrophobic residues in C-terminal domain of γ-crystallins play putative rol...
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Small heat shock proteins alphaA and alphaB crystallin form highly polydisperse oligomers that frustrate protein aggregation, crystallization, and amyloid formation. Here, we present the crystal structures of truncated forms of bovine alphaA crystallin (AAC(59-163)) and human alphaB crystallin (ABC(68-162)), both containing the C-terminal extension that functions in chaperone action and oligome...
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The theory of light scattering indicates that aggregation of the crystalline lens proteins can produce opacity. Furthermore, it is known that calcium increase? in the cataractous lens. We have, therefore, investigated the effectiveness of calcium ion in producmg aggregates of the soluble proteins of the bovine lens. The experimental restdts show: (1) CaCU produce's aggregates of the soluble pro...
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The alpha-, beta- and gamma-crystallins are the major protein components of the vertebrate eye lens, alpha-crystallin as a molecular chaperone as well as a structural protein, beta- and gamma-crystallins as structural proteins. For the lens to be able to retain life-long transparency in the absence of protein turnover, the crystallins must meet not only the requirement of solubility associated ...
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BACKGROUND We highlight an unrecognized physiological role for the Greek key motif, an evolutionarily conserved super-secondary structural topology of the βγ-crystallins. These proteins constitute the bulk of the human eye lens, packed at very high concentrations in a compact, globular, short-range order, generating transparency. Congenital cataract (affecting 400,000 newborns yearly worldwide)...
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ژورنال
عنوان ژورنال: Accounts of Chemical Research
سال: 2020
ISSN: 0001-4842,1520-4898
DOI: 10.1021/acs.accounts.0c00014